You might wonder what plants have to do with peripheral nervous system receptors. It does seem a little odd to associate the two. However there's an article in yesterday's issue of Nature (May 30, 2007) regarding the menthol receptor TRPM8 and how it senses cold. In so doing, the receptor illuminates a mechanism that mediates how the body experiences strong stimuli like temperature that can cause pain. As such, the receptor -- known as menthol receptor TRPM8 -- provides a target for studying acute and chronic pain, as can result from inflammatory or nerve injury, the researchers say, and a potential new target for treating pain. The senior author on this paper is David Julius, chairman and professor of physiology at UCSF. In 2002, his lab discovered that the TRPM8 receptor was activated by chemical cooling agents such as menthol, a natural product of mint, and cool air. According to Dr Julius, "It's been known for years that menthol and related cooling agents evoke th...